Acute Interstitial Nephritis and Checkpoint Inhibitor Therapy
نویسندگان
چکیده
منابع مشابه
Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma
Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases including colitis, endocrinopathies and nephritis. Here, we report a case of a 75-year-old man with metastatic malignant melanoma treated with a combination of nivolumab (an...
متن کاملProton pump inhibitor-induced acute interstitial nephritis.
AIM To investigate the association between the use of proton pump inhibitors (PPIs) and acute interstitial nephritis (AIN). METHODS The Netherlands Pharmacovigilance Centre Lareb received seven case reports of AIN induced by various PPIs. In five of the reports it was mentioned that the diagnosis was confirmed by a renal biopsy. RESULTS The time to onset varied between hours to 4 months. In...
متن کاملAcute interstitial nephritis.
Acute interstitial nephritis (AIN) represents a frequent cause of acute kidney injury, accounting for 15-27% of renal biopsies performed because of this condition. By and large, drug-induced AIN is currently the commonest etiology of AIN, with antimicrobials and nonsteroidal anti-inflammatory drugs being the most frequent offending agents. Pathogenesis is based on an immunologic reaction agains...
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A case of acute oliguric renal failure following gentamicin and linocomycin therapy is described. Renal biopsy showed an acute interstitial nephritis. This was associated with high serum gentamicin levels and the later development of ototoxicity. Withdrawal of antibiotics and conservative measures was followed by rapid recovery of renal function. Attention is drawn to the association between ge...
متن کاملHypercalcaemia and acute interstitial nephritis associated with omeprazole therapy.
Keywords: acute interstitial nephritis; acute renal fail-1+ proteinuria. There was no clinical evidence of foetal ure; hypercalcaemia; omeprazole distress. Omeprazole therapy was commenced.
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ژورنال
عنوان ژورنال: Kidney360
سال: 2020
ISSN: 2641-7650
DOI: 10.34067/kid.0000152019